Trypanosomosis, caused by Trypanosoma evansi, is an economically significant disease of livestock.Systematic antigenic variation by the parasite has undermined prospects for the development of a protective vaccine that targets the immunodominant surface antigens, encouraging exploration of alternatives.The paraflagellar rod (PFR), Cup constituent p
Neonates have an immature immune system which cannot adequately protect against infectious diseases.Early in life, immune protection is accomplished by maternal antibodies transferred from mother to offspring.However, decaying maternal antibodies inhibit vaccination as is examplified by the inhibition of seroconversion after measles vaccination.Thi
Abstract The dominant bacteria in the hindgut of calves play an important role in their growth and health, which could even lead to lifelong consequences.However, the identification of core probiotics in the hindgut and its mechanism regulating host growth remain unclear.Here, a total of 1045 fecal samples were analyzed by 16S rRNA gene sequencing
Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a neurodegenerative disorder with a poorly understood molecular mechanism.It is caused by mutations in Pantothenate Kinase, the first enzyme in the Coenzyme A (CoA) biosynthetic pathway.Here, we developed a Drosophila model of PKAN (tim-fbl flies) that allows us to continuously monitor the